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Ruth O'Regan, MD

Professor and Vice Chair for Educational Affairs
Department of Hematology and Medical Oncology

Chief of Hematology and Medical Oncology
Georgia Cancer Center for Excellence, Grady Memorial Hospital

Hematology Oncology Fellowship Program, Emory University

Louisa and Rand Glenn Family Breast Cancer Research

Medical Director
Emory Breast Center

Distinguished Cancer Scholar
Georgia Cancer Coalition

Breast Cancer Translational Research Program

Dr. Ruth O’Regan obtained her medical degree from University College, Dublin and completed initial training at the Mater Hospital in Dublin, Ireland. She completed her residency at the Medical College of Wisconsin and Northwestern University and her fellowship in Hematology and Oncology at Northwestern University. She was on faculty at Northwestern University until she moved to Emory University in 2003 to direct the breast cancer program. Dr. O’Regan is a Georgia Cancer Coalition Distinguished Cancer Scholar and was named the Louisa and Rand Family Chair in Breast Cancer Research in 2009 for her efforts in developing the breast program at Winship Cancer Institute.

Full Clinical Bio >>

Research Interests

The goal of Dr. O’Regan’s research is to determine mechanisms of resistance to current therapies in breast cancer and develop new therapies that can be evaluated in clinical trials. Prior to joining the faculty at Emory, she worked in the laboratory of Dr Craig Jordan, focused on the mechanisms of resistance to tamoxifen and other hormonal agents in estrogen receptor-positive breast cancer. She has continued this research interest while at Emory and is accruing patients to a novel clinical trial based on her research findings at Northwestern. Her laboratory is currently focused on signaling pathways in triple negative breast cancer, and how these pathways can be targeted therapeutically. A specific focus is on the PI3Kinase-mTOR pathway and how inhibiting mTOR can sensitize breast cancer cells to upstream growth factor inhibitors. Some of her research findings in this area have led to the development of a novel clinical trial for patients with metastatic breast cancer.

Dr. O’Regan is the principal investigator on 10 trials currently ongoing at Winship and oversees several other trials that are led by her colleagues in the breast cancer program.

Dr. O’Regan has published more than 60 medline-indexed, peer-reviewed papers and reviews on breast cancer-related topics. She has served on multiple grant review committees and reviews manuscripts for multiple journals. She has spoken extensively in both national and international venues on breast cancer.


View publications on PubMed

Clinical Trials

View clinical trials at Winship Cancer Institute