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ARM Ruhul Amin, PhD

Assistant Professor
Emory School of Medicine

Dr. Amin obtained his B. Pharm and M. Pharm from Dhaka University, Bangladesh and received his PhD from Nagoya University School of Medicine, Japan in 2003. After completing his PhD, Dr. Amin moved to the USA and completed 3 years of postdoctoral training at Case Western Reserve University and Case Comprehensive Cancer Center. In 2007, he joined the Winship Cancer Institute of Emory University as a Junior Faculty in Dr. Dong M. Shin’s group and was promoted to a full faculty member in 2009. In 2009, he received a Career Development Award from the Emory Head and Neck Cancer SPORE for his outstanding proposal on chemoprevention of head and neck cancer with the natural compounds EGCG and luteolin.

Research Interests

The goal of Dr. Amin’s research is to identify an effective mechanism to prevent the progression of premalignant lesions of the head and neck or lung to invasive cancers. To achieve his goal, Dr. Amin is working in close collaboration with several prominent physician scientists, including Dr. Dong Moon Shin and Dr. Fadlo Khuri. Due to ethical issues, patients with premalignant lesions should not be exposed to toxic chemotherapy drugs, therefore Dr. Amin is focusing on natural dietary compounds which are much safer than chemotherapy agents or targeted drugs. Recently, he has identified that a combination of green tea polyphenol EGCG and another polyphenol luteolin, which is abundantly present in green vegetables including artichoke and broccoli, has synergistic antitumor effects both in vitro and in vivo. Dr. Amin and his research team are now planning to test this combination in the clinic with an attempt to prevent progression of premalignant lesions of head and neck and lung. Dr. Amin is also interested in the chemopreventive properties of other natural compounds including curcumin (from the Indian spice turmeric) and resveratrol (a major constituent of grape fruits and red wine). Dr. Amin also established a collaboration with scientists from Ohio State University to develop potent curcumin analogs for cancer prevention and therapy.

Dr. Amin is also interested in identifying molecular targets responsible for the antitumor and chemopreventive efficacy of natural compounds. His major interest is to study the DNA damage pathways, EGFR-mediated pathways and AKT-mediated pathways. So far, Dr. Amin has published 29 articles in reputed peer review journals including JCO, PNAS, Cancer Research, Oncogene, JBC and Cancer Prevention Research. He has also presented more than 30 abstracts in different national and international conferences and symposia.

Publications

View publications on PubMed