Emory School of Medicine
Dr Jun Fan obtained his PhD from University of Science and Technology of China in 2008 and was trained as postdoctoral fellow in Dr. Jing Chen's laboratory at the Winship Cancer Institute of Emory University before he was promoted to Instructor in 2012. Dr. Fan has extensive publications in major peer-reviewed journals such as Molecular Cell, Cancer Cell, Nature Communications, MCB and JBC. He received a Career Development Award from the Emory Head and Neck Cancer SPORE in 2012.
Dr. Fan is interested in the signaling basis of oncogenesis and cancer metabolism with a particular focus on how the mitochondrial localized tyrosine kinases and acetyltransferase/deacetylase regulate the mitochondria function to contribute to the tumorigenesis and disease progression. Warburg effect describes that cancer cells take up more glucose than normal tissue and favor aerobic glycolysis more than mitochondrial oxidation of pyruvate. Such a metabolic change allows cancer cells to reply more on glycolysis, which is due in part to attenuated mitochondrial function through inhibition of pyruvate dehydrogenase complex (PDC), which links glycolysis to the oxidative phosphorylation and is crucial for glucose homoeostasis. Using proteomics and "targeted” lentiviral shRNA library screen based approaches, Dr. Fan elucidated the signaling mechanisms by which post-translational modifications such tyrosine phosphorylation and lysine acetylation regulate several key components of PDC, including pyruvate dehydrogenase (PDH) and upstream PDH kinase (PDK) and phosphatase (PDP), providing a metabolic advantage in cancer cells to promote the Warburg effect and tumor growth.
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