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Georgia Zhuo Chen, PhD

Associate Professor
Emory School of Medicine

Dr. Georgia Zhuo Chen received her PhD from Louisiana State University, USA, in 1989. After postdoctoral training, she received her first faculty position at the University of Texas Dental Branch, as a Research Assistant Professor in 1992. She then was elevated to the tenure track position at M.D. Anderson Cancer Center in 1998. In 2002, Dr. Chen joined the University of Pittsburgh Cancer Institute as an Associate Professor. Two years later, she joined Emory University, Winship Cancer Institute with the same title. Dr. Chen is a Georgia Cancer Coalition Distinguished Cancer Scholar. Including her studies at the University of Texas Dental Branch, M.D. Anderson Cancer Center, and the University of Pittsburgh Cancer Institute, Dr. Chen has conducted research in the areas of lung and head and neck cancers for nineteen years.

Research Interests

Dr. Chen’s research focuses on the metastasis of head and neck cancer (Chen, Current Cancer Drug Targets, 7:613-622, 2007), signal transduction pathways in cancer cells (Choi, et al., Molecular Therapeutics, 4:1448-1455, 2005), prognostic and therapeutic biomarkers, anticancer therapeutic drugs for treatment of cancer (Zhang, et al., Clin Cancer Res., 10:8451-8459, 2004; Muller, et al., Cancer, 113:97-107, 2008; Zhang, et al., Int. J Cancer, 123:1005-1014, 2008), and usage of nanotechnology in cancer research and clinical application (Davis, et al., Nat Rev Drug Discovery, 7:771-782, 2008; Wang et al., Am Chem Soc Nano, 3:3165-74, 2009; Chen, Trend in Mol  Med, 16:594-602, 2010; Huang et al., Nano Res.,3;61-68, 2010). She has established a human xenograft metastatic mouse model for head and neck cancer, which has been used in studying the biology of cancer and in the evaluation of therapeutic agents for cancer treatment (Zhang, et al., Cancer, 95:1663-1672, 2002; Zhang, et al., Clin Exp Metastasis, 23:209-222, 2006; Zhang, et al.,  Br J. Cancer. 99:1684-1694, 2008). Dr. Chen is a well-trained molecular oncologist with experience in the molecular analyses of oncogene expression, gene regulation, cellular signal transduction, and using animal models for lung and head and neck cancer. As Principal Investigator (PI) in the study of head and neck cancer, her work has been supported over the past few years by several awards from the US National Institutes of Health (NIH). Currently, she is a Project Leader for the Head and Neck Cancer SPORE supported by NIH, and a project funded by the US Department of Defense. She also served as PI on a project for identifying metastasis–related proteins in head and neck cancer using nanotechnology, and as a co-investigator for several projects related to prevention and treatment of lung and head and neck cancers using targeted small molecules and nanotherapeutic drugs. These studies have generated 72 publications in peer-reviewed journals.

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Publications

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