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To understand these terms consider the following hypothetical example 1000 patients are randomized to receive either heparin or placebo. In the heparin group, adverse events (death, or MI ) occurred in 10% (50 of 500). For those treated with placebo, the adverse event rate was 20% (100 of 500). It is convenient to set up a contingency table
to assist data analysis
In other terms,
"the relative
risk of an adverse event in heparin treated patients is 50%"
"the risk of an adverse event was reduced by 50%"
2) NNT= 1/ (RRR X CER) NNT= 1/(0.5X 0.2)= 10 "You need to treat 10 patients to avoid one adverse event" NNT is in some ways more intuitive and informative
than RR or RRR. However, a full appreciation of NNT's requires
a little more reading
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