Dr. Ben Hampstead (Department of Rehabilitation Medicine) and colleagues research extends their pioneering use of cognitive rehabilitation techniques to enhance memory and visuospatial functions and brain activity in functional MRI studies in subjects with amnestic Mild Cognitive Impairment.
Led by Dr. Peng Jin (Department of Human Genetics), this project will increase the understanding of the role of small RNAs in AD, known as miRNAs, and the genes they regulate. This knowledge will provide both insight into the molecular changes seen in AD and will also potentially provide new targets for further research and therapeutic development.
Dr. David Weinshenker (Department of Human Genetics) and colleagues have recently discovered that degeneration of a group of brain cells in the locus coeruleus that contain norepinephrine has a profound influence on neuro-inflammation and progression of Alzheimer's disease in animal models. The project which will further understanding of the role of the locus coeruleus in the development of Alzheimer's disease and facilitate development of novel treatment strategies addressing underlying disease pathology.